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Transcriptional activity of promoters by WT Towne IEP86 and IEP86 variants made in the Towne IEP86 background. Transfections and analyses were similar to those described in the legend for Fig. 2. The panels show activation of the simple Tef-TATA promoter (A), the UL112-113 promoter (B), and the ICP36 promoter (C). The effect of the +S258 IEP86 variant on each promoter is also shown (D). Basal promoter activity, shown in each panel by the column labeled with the letter B, is set at 1.
