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TCD8+ response of BALB/c mice to boiled virus. Splenocytes from BALB/c mice immunized with infectious (A) or boiled (B) PR8 were restimulated in vitro for 7 days and then used in a 51Cr-release assay at the indicated effector-to-target cell ratio (E:T). P815 target cells were infected with PR8 or sensitized with synthetic peptides as indicated. Similar results were obtained in an additional experiment.
