FIG. 4.

Long-term effect of polyclonal Ab (pAb) transfer on JHMV pathogenesis. Mortality of B-cell-deficient mice following transfer of neutralizing or nonneutralizing pAb at days 9, 12, and 17 p.i. (A). Virus titers were determined at 40 days p.i. in the brains of μMT mice receiving three doses (pAb-3x) or at 45 days p.i. in mice that received a fourth dose (pAb-4x) of the neutralizing polyclonal Ab on day 24 p.i. (B). The dashed line indicates the limit of viral detection. Data represent the average of at least three separate experiments. Error bars indicate standard errors of the means. gm brain, gram of brain.