TABLE 1.
Properties of the Anti-S protein specific MAb
| Antibody | Isotype | Titera | Neutralization | Neutralization activity (μg)c | Fusion inhibition | Fusion inhibition activity (μg)c | Reference |
|---|---|---|---|---|---|---|---|
| pAb-1 | Polyclonal | 4.9 | + | 80 | + | 80 | 23 |
| J.7.2 | IgG2b | 6.3 | + | 2.5 | + | 50 | 10 |
| J.2.6 | IgG2b | 7.7 | + | 0.065 | + | 26 | 10 |
| J.7.5 | IgG2b | 4.9 | + | 3 | ND | ND | 10 |
| 5B1 | IgG1 | 4.9 | + | 150 | ND | ND | 4 |
| 5B9 | IgA | 7.7 | + | 200 | ND | ND | 4 |
| J.2.5 | IgG2a | 4.9 | NDb | ND | + | 30 | 10 |
| J.1.2 | IgG2b | 4.9 | ND | ND | ND | ND | 10 |
| J.1.16 | IgG2b | 6.3 | ND | ND | ND | ND | 10 |
| J.7.1 | IgG2a | 5.6 | ND | ND | ND | ND | 10 |
a
Titer (log10) determined by ELISA.
b
ND, not detectable.
c
Activity determined by calculating the neutralization or fusion inhibition titer based on Ab concentration.