FIG. 6.

Model of receptor-mediated PV uncoating. The south wall of the canyon is probably responsible for forming the initial binding state of the PV-CD155 complex. The interaction between the north wall of the canyon and CD155 immediately above the hydrophobic binding pocket helps the release of the pocket factor, thus destabilizing the virus. Heating increases the structural “breathing” of the virus, thus providing the conformational change required for forming the “activated state” of the PV-CD155 complex.