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. 2006 Jul 15;20(14):1885–1898. doi: 10.1101/gad.1424106

Figure 2.

Figure 2.

The N-terminal domain of GW182 is required for P-body targeting. (A) Domain architecture of GW182 and related proteins. (N-GW) N-terminal GW repeats; (M-GW) middle GW repeats; (C-GW) C-terminal GW repeats; (UBA) ubiquitin-associated domain; (Q-rich) region rich in glutamine; (RRM) RNA recognition motif. Orange and red boxes I and II indicate two conserved motifs within the N-terminal GW repeats. Numbers under the protein outline represent amino acid positions at fragment boundaries for the Drosophila protein. The protein domains sufficient for the localization to P-bodies and the interaction with AGO1 are indicated. (B) Confocal fluorescent micrograph of S2 cells stained with anti-GW182 antibodies. (C–F) Confocal fluorescent micrographs of S2 cells expressing HA-GW182 and/or GFP-DCP1. Bar, 5 μm.