Skip to main content
. 2003 Mar 10;100(6):3245–3250. doi: 10.1073/pnas.0330217100

Figure 4.

Figure 4

Regulation of cyclin D1 and cyclin D2 by the Wnt pathway in human colon cancer cells. (A and B) ChIP analysis of Cyclin D1 and Cyclin D2 promoters in HCT116 cells, treated as indicated. On the Cyclin D2 promoter, Pitx2 is detected but LEF1 is not detected. On the Cyclin D1 promoter, LEF1 is detected, as is Pitx2. (C) A block of Cyclin D2 expression in HCT116 cells in single-cell nuclear microinjection by αPitx2 IgG or by expression of a dominant-negative form of Pitx2 (Pitx2 N terminus).