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. 2003 Mar 10;100(6):3445–3449. doi: 10.1073/pnas.0635898100

Figure 5.

Figure 5

GM3S−/− mice are protected from high-fat diet-induced insulin resistance. Groups of GM3S−/− and GM3S+/+ male mice were placed on a 45% high-fat diet for 10 weeks. The diet was started when the mice were 6–8 weeks old. (A) Glucose tolerance tests on GM3S+/+ and GM3S−/− mice after the high-fat diet (n = 8, +/+; n = 10, −/−). *, P < 0.05 by Student's t test; GM3S−/− vs. GM3S+/+. (B) Insulin levels of GM3S+/+ and GM3S−/− mice after the high-fat diet, when fed and after fasting for 14 h (n = 12 each genotype). *, P < 0.05 by Student's t test; GM3S−/− vs. GM3S+/+. (C) Whole body and skeletal muscle glucose uptake of GM3S+/+ and GM3S−/− mice after the high-fat diet as determined by euglycemic–hyperinsulinemic clamps (n = 4 each genotype). *, P < 0.05 by Student's t test; GM3S−/− vs. GM3S+/+. (E) The percent suppression of endogenous glucose production (EGP) in livers GM3S+/+ and GM3S−/− mice after the high-fat diet as determined by euglycemic–hyperinsulinemic clamps (n = 4 each genotype). *, P < 0.05 by Student's t test; GM3S−/− vs. GM3S+/+.