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. 2006 Jul 6;25(14):3257–3263. doi: 10.1038/sj.emboj.7601220

Figure 2.

Figure 2

A structurally intact TRAF3 molecule is required for antiviral activity. (A, E) Traf3−/− MEFs were reconstituted with the indicated constructs. (B, F) Expression was monitored by immunoblotting. (C, G) Reconstituted cells were then infected with Sendai virus for 24 h and IFNα levels in the supernatants were assayed by ELISA. (D) Cells from (B) were infected with VSV-GFP. VSV replication was monitored by flow cytometry. NS designates a nonspecific band. Dotted line indicates the limit of detection for the IFNα ELISA.