Figure 1.

Generation and aging of AKXD-Blm^m3 mice. (A) Mating scheme for generating AKXD-Blm^+/+ and AKXD-Blm^m3/m3 mice. Mice carrying the Blm^tm3Brd mutation were backcrossed three or six times to the AKXD-10, -14, or -27 inbred mouse strains. N₃ or N₆ backcrossed Blm^+/m3 mice were then intercrossed and the Blm^+/+ and Blm^m3/m3 progeny aged for tumors. (B) AKXD-Blm^m3/m3 (n=137) mice die earlier of retrovirus-induced lymphoma than AKXD-Blm^+/+ (n=116) mice. AKXD-Blm^m3/m3 mice and AKXD-Blm^+/+ mice were monitored for lymphoma development. The age in days at the time of death is plotted for each Blm^+/+ and Blm^m3/m3 mouse. P<0.01 by Log-Rank and Wilcoxon test.