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. 2006 Jul 6;25(14):3335–3346. doi: 10.1038/sj.emboj.7601222

Figure 2.

Figure 2

The tyrosine kinase c-Src conveys dsRNA-induced Akt activation. (A) Human mDCs were left untreated or treated with 100 μg/ml dsRNA for various times or 0.5 μg/ml LPS for 20 min. (B) Human mDCs were pretreated or not with PP2 or 25 μM PP3 before addition of 100 μg/ml dsRNA and treatment for 50 min. Cell lysates were immunoblotted (IB) for the indicated proteins. (C) HEK cells expressing Flag-tagged TLR3 were stimulated with dsRNA (100 μg/ml) for the indicated time periods and cell lysates were immunoprecipitated (IP) with anti-Flag, anti-p85, or control IgG and immunoblotted (IB) for the indicated proteins.