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. 2006 Jul 28;2(7):e120. doi: 10.1371/journal.pgen.0020120

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© 2006 Eppinger et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Fragmentation of the vacA (vacuolating cytotoxin) gene (red) into 13 fragments and import of neuACB, cst, cst (blue-green) within Sheeba. neuACB encode acylneuraminate cytidyltransferases and cst encodes a sialyltransferase.

(B) Translocation of a duplicate of the fragmented vacA gene to a different genomic location. The duplicated vacA gene (red) contains the same fragmentation pattern and differs by only one sequence polymorphism in 3,815 bp from that in part A, indicating that the duplication is recent and occurred after the fragmentation event. Next to the duplicated vacA gene are located three genes (light blue) that are unique to H. acinonychis.

(C) Homologies of the neuACB, cst, cst gene cluster from part A with syntenic clusters in C. jejuni NCTC11168 and the B. cereus virulence plasmid pBC218.