Table 5.

Defensin genotypes and infection outcomes.

Polymorphism	Genotype	Physician visits‡§	Part 1 p Value*	Part 2 p Value†	Days in bed‡ll	Part 1 p Value*	Part 2 p Value†
DEFA1/DEFA3
	DEFA1 only	0.22 (0.07)	0.23	0.05	0.38 (0.16)	0.60	0.36
	DEFA1/DEFA3	0.28 (0.02)			0.51 (0.06)
DEFB1 G-20A
	GG	0.27 (0.04)	0.85	0.88	0.49 (0.10)	0.86	0.98
	GA	0.26 (0.03)			0.48 (0.08)
	AA	0.30 (0.05)			0.54 (0.11)
DEFB1 C-44G
	CC	0.28 (0.03)	0.81	0.42	0.53 (0.07)	0.93	0.14
	CG	0.27 (0.04)			0.44 (0.10)
	GG	0.18 (0.10)			0.28 (0.24)
DEFB1 G-52A
	GG	0.29 (0.04)	0.67	0.62	0.47 (0.08)	0.81	0.29
	GA	0.25 (0.03)			0.47 (0.08)
	AA	0.30 (0.06)			0.62 (0.14)

Definition of abbreviations: DEFA = alpha-defensin; DEFB = beta-defensin.

*Part 1 of the two-part model involves modeling whether an individual has any physician visits or any days in bed due to lower respiratory infection. P values for global haplotype association derived from logistic regression analysis. Decline in lung function status was included as a factor in the analysis.

†Part 2 of the two-part model involves modeling the average number of physician visits or days in bed due to lower respiratory infection given that it is greater than zero. P values for global haplotype association derived from gamma regression analysis. Decline in lung function status was included as a factor in the analysis.

‡Mean (SE).

§Mean number of visits to a physician for lower respiratory infections per year.

llMean number of days kept in bed for lower respiratory infections per year.