Table 1.

Results of surgery and stereotactic radiosurgery (SRS) for brain metastases

Reference	n (patients and lesions)	Prescribed dose (median; range [Gy])*	Median OS	1-year PFS (%)
Patchell et al. 1990 [1]	25/25	Surgery	9.5	80
Patchell et al. 1998 [2]	49/49	Surgery	11.0	82
Pirzkall et al. 1998 [3]	236/311	20; 10–30	5.5	89
Cho et al. 1998 [4]	73/136	17.5; 6–50	7.8	80
Kocher et al. 1998 [5]	106/157	20; 12–25	8.0	85
Sneed et al. 1999 [6]	62/118a 43/117b	18; 15–22 17.5; 15–22	11.3 11.1	80 86
Varlotto et al. 2003 [7]	137/208	16; 12–25	Not given	90
Andrews et al. 2004 [8]	164/269c	Not given; 15–24	6.5	82
Bhatnagar et al. 2006 [9]	205/4-18 lesions eachd	16; 12–20	8.0	71

OS: overall survival in months; PFS: progression-free survival; ?: data not reported

* Prescription isodose or point varied, some series included SRS plus WBRT

^a SRS only

^b SRS plus WBRT (no significant difference in OS and PFS between both groups)

^c SRS plus WBRT

^d SRS plus/minus WBRT