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. 2006 Aug 1;116(8):2272–2279. doi: 10.1172/JCI28414

Figure 2. Immunofluorescence detection of podocyte proteins.

Figure 2

Frozen sections of normal (left) and Lamb2–/– (right) kidneys at P7 and P28 were stained for integrin α3 (Intα3; A–D), nephrin (E–H), and podocin (I–L). There were no detectable changes in intensity or distribution of these proteins in young mice. However, with age and disease progression, there was a reduction in intensity; all 3 seemed to lose their normal linear distribution and showed a more diffuse granular pattern. This likely reflects the retraction of FPs and reduced SD density. Magnification, P7, ×200; P28, ×600.