Skip to main content
. 2002 Apr 15;16(8):984–993. doi: 10.1101/gad.973602

Figure 4.

Figure 4

Effects of p53 induction on PI3K-p110α and PTEN expression. Northern (A) and Western (B) blot analyses of EB1 cells induction of p53 by 100μM zinc resulted in transcriptional activation of p21 and MDM2. A fourfold induction in PTEN expression and a sixfold down-regulation of PIK3CA expression was detected by both Northern and Western blot analyses. A decrease in phosphorylated AKT levels resulted from the p53-related PTEN induction and PIK3CA inhibition. (C,D,E) Results from analysis of synergism between p53 induction and PI3K inhibition. Significant synergism was demonstrated with p53 induction by zinc and PI3K inhibition with LY294002 in EB1 cells.