Table 3.

 Stepwise multivariate Cox proportional hazard analysis of variables identified in univariate analysis as risk factors for myocardial infarction after age 60

Risk factor	Excluding serum proinsulin			Including serum proinsulin
	Hazard ratio (95% CI)	P value		Hazard ratio (95% CI)	P value
Antihypertensive treatment (n=291)
Change in glucose	1.50 (1.25 to 1.78)	0.0001		1.29 (1.06 to 1.55)	0.01
LDL:HDL cholesterol ratio	1.32 (1.10 to 1.51)	0.004		1.28 (1.05 to 1.49)	0.02
Intact proinsulin	NA	NA		1.33 (1.01 to 1.78)	0.05
No antihypertensive treatment (n=1358)
Change in glucose	1.04 (0.86 to 1.24)	0.72		0.99 (0.81 to 1.21)	0.98
LDL:HDL cholesterol ratio	1.42 (1.22 to 1.67)	<0.0001		1.39 (1.18 to 1.61)	0.0001
Change in systolic blood pressure	1.24 (1.03 to 1.48)	0.02		1.26 (1.01 to 1.55)	0.04
Intact proinsulin	NA	NA		1.38 (1.13 to 1.67)	0.0016

LDL=low density lipoprotein; HDL=high density lipoprotein; NA=not applicable. 

^*Hazard ratios for a one standard deviation (given in table 1) variation in the variables.