TABLE 2.
GMs of MICs and MIC50s and MIC90s of 11 agents for isolates of genomic DNA groups 2, 3, and 13TU from clinical specimens from patients in ICU and general wards, carriage sites of patients, hospital staff members, and community volunteers, and food and soil samplesa
| Source of isolates | Genomic DNA groupb | Valuec | AMK | GEN | NET | CAZ | IPM | SUL | CIP | NAL | TET | SMX | RIF |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ICU specimens | 2 (19) | GM | 2.4 | 3.6 | 0.9 | 34.4 | 0.3 | 4.1 | 5.2 | 39.8 | 26.7 | 39.8 | 2.5 |
| MIC50 | 1 | 4 | 1 | 64 | 0.5 | 2 | 8 | 64 | 64 | 64 | 2.0 | ||
| MIC90 | 64 | 64 | 2 | 64 | 1 | 32 | 16 | 128 | 64 | 64 | 8.0 | ||
| 3 (30) | GM | 4.0 | 1.0 | 1.0 | 29.9 | 0.6 | 1.1 | 0.5 | 4.8 | 2.2 | 28.5 | 3.7 | |
| MIC50 | 2 | 0.5 | 1 | 32 | 0.25 | 1 | 0.5 | 4 | 2 | 64 | 2.0 | ||
| MIC90 | 64 | 4 | 8 | 64 | 8 | 4 | 4 | 32 | 8 | 64 | 64.0 | ||
| 13TU (27) | GM | 2.3 | 1.3 | 1.5 | 15.6 | 0.2 | 1.4 | 0.9 | 6.3 | 5.4 | 6.5 | 5.5 | |
| MIC50 | 2 | 1 | 1 | 16 | 0.13 | 1 | 0.5 | 4 | 4 | 4 | 4.0 | ||
| MIC90 | 8 | 8 | 16 | 32 | 0.5 | 2 | 4 | 16 | 64 | 16 | 8.0 | ||
| Ward specimens | 2 (39) | GM | 2.0 | 1.0 | 0.8 | 25.0 | 0.2 | 2.5 | 2.2 | 18.1 | 11.4 | 22.0 | 2.2 |
| MIC50 | 2 | 1 | 1 | 32 | 0.5 | 2 | 1 | 1 | 4 | 16 | 2.0 | ||
| MIC90 | 16 | 64 | 2 | 64 | 0.5 | 32 | 16 | 128 | 64 | 64 | 4.0 | ||
| 3 (35) | GM | 2.5 | 0.7 | 0.9 | 18.4 | 0.3 | 0.9 | 0.5 | 4.5 | 2.0 | 17.7 | 2.2 | |
| MIC50 | 2 | 0.5 | 1 | 16 | 0.13 | 1 | 0.5 | 4 | 2 | 8 | 2.0 | ||
| MIC90 | 64 | 2 | 2 | 64 | 4 | 1 | 1 | 8 | 4 | 64 | 4.0 | ||
| 13TU (23) | GM | 2.6 | 1.0 | 1.1 | 21.6 | 0.2 | 1.4 | 0.8 | 6.7 | 4.9 | 9.9 | 3.7 | |
| MIC50 | 2 | 1 | 1 | 32 | 0.13 | 1 | 0.5 | 4 | 4 | 8 | 4.0 | ||
| MIC90 | 4 | 2 | 2 | 32 | 0.25 | 4 | 2 | 16 | 64 | 32 | 4.0 | ||
| Carriage sites of patients | 2 (18) | GM | 0.7 | 0.5 | 0.3 | 4.3 | 0.5 | 1.0 | 0.7 | 4.0 | 4.3 | 6.1 | 2.1 |
| MIC50 | 0.5 | 0.5 | 0.25 | 4 | 0.5 | 1 | 0.5 | 4 | 2 | 4 | 2.0 | ||
| MIC90 | 2 | 1 | 0.5 | 16 | 0.5 | 2 | 2 | 16 | 64 | 64 | 4.0 | ||
| 3 (21) | GM | 0.8 | 0.5 | 0.4 | 3.7 | 0.5 | 0.9 | 0.4 | 4.0 | 1.8 | 4.4 | 2.4 | |
| MIC50 | 0.5 | 0.5 | 0.25 | 4 | 0.5 | 1 | 0.5 | 4 | 2 | 4 | 2.0 | ||
| MIC90 | 2 | 1 | 1 | 4 | 0.5 | 2 | 1 | 8 | 2 | 8 | 4.0 | ||
| 13TU (27) | GM | 1.7 | 1.2 | 0.9 | 4.2 | 0.4 | 0.6 | 0.5 | 3.9 | 3.1 | 4.9 | 3.9 | |
| MIC50 | 2 | 1 | 1 | 4 | 0.5 | 1 | 0.5 | 4 | 2 | 4 | 4.0 | ||
| MIC90 | 2 | 4 | 2 | 8 | 0.5 | 1 | 1 | 8 | 64 | 64 | 8.0 | ||
| Carriage sites of hospital staff members | 3 (10) | GM | 0.8 | 0.5 | 0.3 | 3.0 | 0.6 | 0.8 | 0.4 | 3.5 | 1.1 | 2.6 | 2.6 |
| MIC50 | 0.5 | 0.5 | 0.5 | 4 | 0.5 | 1 | 0.5 | 4 | 2 | 4 | 2.0 | ||
| MIC90 | 2 | 1 | 1 | 4 | 1 | 1 | 1 | 4 | 2 | 4 | 16.0 | ||
| Carriage sites of community volunteers | 3 (12) | GM | 0.9 | 0.5 | 0.3 | 4.2 | 0.3 | 0.8 | 0.3 | 3.4 | 1.3 | 3.4 | 2.2 |
| MIC50 | 1 | 0.5 | 0.25 | 4 | 0.25 | 1 | 0.5 | 4 | 2 | 4 | 2.0 | ||
| MIC90 | 2 | 1 | 0.5 | 16 | 0.5 | 1 | 1 | 8 | 2 | 4 | 4.0 | ||
| Food and soil samples | 3 (21) | GM | 1.4 | 0.7 | 0.6 | 14.0 | 0.1 | 0.5 | 0.6 | 4.9 | 1.9 | 11.1 | 2.8 |
| MIC50 | 2 | 1 | 0.5 | 16 | 0.13 | 0.5 | 0.5 | 4 | 2 | 8 | 4.0 | ||
| MIC90 | 2 | 1 | 1 | 16 | 0.25 | 0.5 | 1 | 8 | 2 | 64 | 4.0 |
a
Abbreviations: AMK, amikacin; GEN, gentamicin; NET, netilmicin; CAZ, ceftazidime; IPM, imipenem; SUL, sulbactam; CIP, ciprofloxacin; NAL, nalidixic acid; TET, tetracycline; SMX, sulfamethoxazole; RIF, rifampin.
b
Numbers in parentheses indicate the number of isolates examined.
c
All values are given in micrograms per milliliter.