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Dcr-2 and R2D2 coordinately bind siRNA duplex. The gel-shift assays were performed by incubating 5′ radiolabeled siRNA duplex and 10-pmol recombinant Dcr-2/R2D2 complex (lane 1), Dcr-2 (lane 2), MBP-R2D2 (lane 3), Dcr-2 + MBP-R2D2 (lane 4), R2D2 (lane 5), and Dcr-2 + R2D2 (lane 6). The arrowhead points to free siRNA. Two arrows refer to the Dcr-2/MBP-R2D2/siRNA and Dcr-2/R2D2/siRNA complexes, respectively.
