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Detailed view of structural relationships among information models, ontology, and semantic metadata. CDEs are derived from ontology-annotated UML models. The figure depicts a single class with two attributes generating (a) CDE with a non-enumerated value domain, and (b) CDE with an enumerated value domain. A single NCI Thesaurus annotation is shown for the concept Cutaneous Melanoma. The relationship of the ISO/IEC metadata to UML model and NCI Thesaurus is also shown.
