Table 1.

NCI Thesaurus sample concept with new subtype concept

A. Acral lentiginous melanoma (C4022)(existing concept defined with both text and description logic role relationships)
Parent: Cutaneous melanoma
Definition: A form of melanoma occurring most often on the plantar, palmar, subungual, and periungual skin. It presents as a pigmented macular lesion with irregular borders. Morphologically, it consists of atypical spindled and dendritic melanocytes. The epidermis is often hyperplastic and there is pagetoid infiltration of the epidermis by anaplastic cells.
<Other synonyms, codes, etc.>
Description logic role relationshipsInherits some values from more general concepts, adds five new ones.
Anatomy roles:
Disease_Has_Primary_Anatomic_Site	Skin of the extremity
Disease_Excludes_Primary_Anatomic_Site	Skin of the trunk
Disease_Has_Normal_Tissue_Origin	Skin tissue
Pathology & finding roles:
Disease_Has_Normal_Cell_Origin	Melanocyte
Disease_Has_Abnormal_Cell	Dendritic melanoma cell
Disease_Has_Abnormal_Cell	Spindle melanoma cell
Disease_Has_Finding	Cutaneous involvement
Disease_Has_Finding	Macular lesion
Molecular abnormality roles:
Disease_May_Have_Molecular_Abnormality	BRAF gene mutation
Disease_May_Have_Molecular_Abnormality	NF-2 tumor-suppressor gene inactivation
B. Mucosal lentiginous melanoma (C48622)(subtype concept added to support CAP protocol, with new text definition and role)
Parent: Acral lentiginous melanoma
Definition: An acral lentiginous melanoma affecting mucosal surfaces.
<Other synonyms, codes, etc.>
Description logic role relationshipsInherits all values from parent concept above, add one to logically distinguish this concept.
Additional anatomy role:
Disease_Has_Normal_Tissue_Origin	Mucosa