TABLE 4.
Median inhibitory and bactericidal titers in serum of gatifloxacin and moxifloxacin over time against anaerobic bacteriaa
| Organism and time point (h) | Gatifloxacin
|
Moxifloxacin
|
||
|---|---|---|---|---|
| SIT (range) | SBT (range) | SIT (range) | SBT (range) | |
| F. nucleatum | ||||
| 2 | 1:4 (<1:2-1:16) | 1:4 (1:2-1:16) | 1:4 (1:4-1:32) | 1:4 (1:4-1:32) |
| 6 | 1:2 (<1:2-1:4) | 1:2 (1:2-1:4) | 1:4 (1:2-1:8) | 1:4 (1:2-1:8) |
| 12 | 1:2 (<1:2-1:4) | 1:2 (<1:2-1:4) | 1:2 (1:2-1:4) | 1:2 (1:2-1:4) |
| 24 | <1:2 (<1:2-1:4) | <1:2 (<1:2-1:4) | 1:2 (<1:2-1:2) | 1:2 (<1:2-1:2) |
| P. melaninogenica | ||||
| 2 | 1:8 (1:4-1:16) | 1:4 (1:4-1:8) | 1:4 (1:2-1:8) | 1:4 (<1:2-1:8) |
| 6 | 1:4 (1:2-1:8) | 1:4 (1:2-1:8) | 1:4 (1:4-1:8) | 1:4 (<1:2-1:4) |
| 12 | 1:4 (1:2-1:8) | 1:4 (1:2-1:8) | 1:4 (1:2-1:4) | 1:2 (1:2-1:4) |
| 24 | 1:2 (<1:2-1:4) | 1:2 (<1:2-1:4) | 1:2 (<1:2-1:4) | 1:2 (<1:2-1:4) |
| P. micros | ||||
| 2 | 1:8 (1:8->1:32) | 1:8 (1:8-1:16) | 1:16 (1:8-1:16) | 1:16 (1:8-1:16) |
| 6 | 1:8 (1:2-1:16) | 1:4 (1:2-1:8) | 1:8 (1:4-1:16) | 1:8 (1:4-1:8) |
| 12 | 1:4 (1:2-1:8) | 1:4 (1:2-1:4) | 1:4 (1:2-1:16) | 1:4 (<1:2-1:8) |
| 24 | 1:2 (<1:2-1:2) | <1:2 (<1:2-1:2) | 1:2 (1:2-1:4) | 1:2 (<1:2-1:4) |
| P. magnus | ||||
| 2 | 1:8 (1:8-1:32) | 1:8 (1:4-1:32) | 1:32 (1:16-1:32) | 1:16 (1:16-1:32) |
| 6 | 1:8 (1:4-1:16) | 1:8 (1:2-1:16) | 1:16 (1:8-1:32) | 1:8 (1:8-1:32) |
| 12 | 1:4 (1:2-1:8) | 1:4 (1:2-1:4) | 1:8 (1:4-1:8) | 1:8 (1:4-1:8) |
| 24 | 1:2 (1:2) | 1:2 (<1:2-1:2) | 1:4 (1:2-1:8) | 1:4 (1:2-1:4) |
SIT, serum inhibitory titer, SBT, serum bactericidal titer.