Figure 4.

(a) Primary HMEC and RAO-4 cells were treated with FTI-277, a potent farnesyl transferase inhibitor, and effects were observed. The membranous ruffles of cells showed a significant flattened morphological appearance after treatment with FTI-277 at 2.5 and 5.0 μM concentrations. Although cellular morphological changes were not observed in primary HMEC at these concentrations, we observed some cell death with FTI-277 treatment at 2.5 and 5.0 μM concentrations. (b) We found a reduction in RAO-4 cell proliferation with FTI-277 treatment at 5.0 μM concentrations. The black bars represent untreated epithelial tumor cells while the white bars represents treated epithelial tumor cells.