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. 2006 Jul 27;398(Pt 1):1–13. doi: 10.1042/BJ20060565

Figure 1. Spatial control of PIPK signalling and local PtdIns(4,5)P2 levels through small G-proteins and compartment-specific targeting factors.

Figure 1

In response to extracellular signals, PIPKs are targeted to specific cellular localizations, most often membranous structures, by specific targeting molecules where interactions with small G-proteins contribute to increased local PtdIns(4,5)P2 [PI(4,5)P2] availability downstream. PIP, PtdInsP.