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. 2006 Jul 27;398(Pt 1):1–13. doi: 10.1042/BJ20060565

Figure 4. Interaction between Ajuba and PIPKIα in conjunction with Rac signalling increases membrane ruffle formation.

Figure 4

Co-ordinated signalling from extracellular signals through phosphoinositide phosphate kinases PIPK and PI3K in concurrence with interaction with Ajuba alters the localization of PIPKIα to sites of membrane ruffle formation where concurrent translocation of and signalling through Rac allows their collective effect of increased membrane ruffle formation. PDGF-R, PDGF receptor; PI3K, phosphoinositide 3-kinase; PI(3,4,5)P3, PtdIns(3,4,5)P3; PI(4,5)P2, PtdIns(4,5)P2.