Table 4.

Principal findings so far

Psychopathology	All areas of psychopathology more frequent in high risk subjects than controls; schizophrenia only developing in high risk subjects
Neuropsychology	High risk subjects performed less well than controls in all tests of intellectual function and on aspects of executive function and memory, some of the latter being related to genetic liability. Further decline in function in those with psychotic symptoms
Brain structure as determined by magnetic resonance imaging	High risk subjects have reduced amygdalo-hippocampal and thalamic volumes compared to controls and larger amygdalo-hippo-campi than schizophrenics
	Prefrontal and thalamic volumes relate to degree of genetic liability. High risk subjects with psychotic symptoms show reduction in temporal lobe volumes