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. 2006 Jul 14;7(8):831–837. doi: 10.1038/sj.embor.7400752

Figure 5.

Figure 5

Genetic interaction between Acvr2b and Alk5 during kidney development and palate closure. (A,B) Whole-mount urogenital system from wild type (WT) (A) and Alk5+/−;Acvr2b−/− mutant (B). Note the unilateral kidney agenesis in the Alk5+/−;Acvr2b−/− mutant. (C,D) Macroscopic view of WT (C) and Alk5+/−;Acvr2b−/− mutant (D) heads. Arrow in (D) points at the cleft palate. (E,F) Skeleton staining of skulls from embryos shown in (C,D). Arrow in (F) points to the cleft palate, which leads to absence of secondary palate. ad, adrenal gland; bl, bladder; ki, kidney; te, testis.