Western blotting assay showing the change of the ERK/Akt/NF-κB, JNK2/c-Jun, STAT3 signaling pathways in the mock-, wild-type LRRC4, or its mutant-transfected U251 cells. (A) Protein levels of phospho-ERK2, Akt, and NFκBp65. (B) Protein levels of JNK2/p-c-Jun and mutant p53. (C) Protein level of STAT3. (D) Protein levels of cyclinD1.