FIG. 1.

Multiple sequence alignment of the Tet 37 sequence with other oxidoreductases by using CLUSTAL W (version 1.82). Flavoprotein from F nucleatum subsp. nucleatum ATCC 255 (GenBank accession number AE010563.1) had 44% identity; Rubredoxin-oxygen oxidoreductase from Desulfovibrio gigas (GenBank accession number Q9F0J6) had 29% identity. Amino acid sequence positions are indicated with numbers, and the blocks named A, B, and C show the possible ADP binding sites, metal binding, and the redox center flavodoxin-like domain (I-YGTM-GNTE----S), respectively. The conserved arginine residue is underlined in the sequence, and the conserved active-site residues are marked with an asterisk.