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. 2003 Apr;47(4):1324–1333. doi: 10.1128/AAC.47.4.1324-1333.2003

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Copyright © 2003, American Society for Microbiology

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FIG. 4. — Relationship between number of key substitutions and susceptibility to PIs. Panel A plots the range of FCs for all seven PIs relative to a number of key substitutions present. The dotted line identifies the position of a 3.0-fold change in susceptibility. Panel B plots the percentage of isolates displaying a ≤3.0-fold change in susceptibility to each of the PIs for isolates containing one to eight key substitutions: atazanavir (⧫), amprenavir (▪), indinavir (▴), lopinavir (◊), nelfinavir (▵), ritonavir (○), and saquinavir (□).