TABLE 1.

Representative data of the 13 selected S. pneumoniae strains

Sample	Range of mutation frequency	Penicillin MIC (μg/ml)	PFGE typea	Sero- type	Sample type
1	1.5-1.6 (× 10−8)	0.12	A	18 F	Blood
2	3.4-3.5 (× 10−8)	0.25	B	19	Blood
3	6.0-6.3 (× 10−10)	2	C	14	Nasal
4	5.9-6.1 (× 10−8)	≤0.01	D	24	Ocular
5	4.4-4.8 (× 10−8)	0.5	E	23 F	Sputum
6	2.1-2.5 (× 10−7)	1	E2	23 F	Nasal
7	4.2-4.6 (× 10−7)	0.12	E3	23 F	BALF
8	3.0-3.3 (× 10−7)	1	B1	19	Blood
9	4.7-5.0 (× 10−7)	0.5	C1	14	Blood
10	4.3-4.7 (× 10−7)	≤0.01	G	18 C	BALF
11	3.5-3.8 (× 10−7)	0.06	G1	23 A	Nasal
12	5.0-5.3 (× 10−7)	≤0.01	H	3	Blood
13	1.0-1.2 (× 10−6)	1	E1	23 F	CSFb

^aPFGE, pulsed-field gel electrophoresis. Data from reference 15.

^bCSF, cerebrospinal fluid.