TABLE 1.
Organism | MIC (μg/ml)a
|
|||
---|---|---|---|---|
MCFG | AMB | ITC | FLC | |
H. capsulatum | ||||
IFM41612 | >64/0.0625 | 0.25/0.125 | 0.0156/0.0156 | 2/4 |
IFM41329 | >64/0.0313 | 0.25/0.0625 | 0.0078/0.0313 | 2/16 |
IFM41330 | >64/0.0313 | 0.125/0.125 | ≤0.0039/0.0313 | 4/16 |
G217B | >64/NTb | 0.5/NT | 0.0156/NT | 1/NT |
B. dermatitidis | ||||
ATCC 26197 | >64/0.0078 | 0.125/0.0156 | ≤0.0039/0.0078 | 2/16 |
ATCC 26198 | >64/0.0156 | 0.125/0.0156 | 0.0156/0.0078 | 4/32 |
ATCC 26199 | 32/0.0313 | 0.125/0.0156 | 0.0078/0.0313 | 1/32 |
IFM40753 | NT/0.0156 | NT/0.0156 | NT/0.0156 | NT/32 |
IFM40754 | 32/0.0156 | 0.125/0.0156 | ≤0.0039/0.0313 | 4/32 |
IFM41634 | 64/0.0078 | 0.125/0.0156 | ≤0.0039/0.0078 | 1/32 |
P. brasiliensis | ||||
IFM41620 | >64/16 | 0.25/0.0156 | ≤0.0039/≤0.0039 | 0.25/0.5 |
IFM41621 | >64/16 | 0.25/0.0078 | ≤0.0039/≤0.0039 | 0.5/0.5 |
IFM41626 | >64/8 | 0.0625/0.0156 | ≤0.0039/≤0.0039 | 0.25/1 |
IFM41632 | >64/16 | 0.125/0.0313 | ≤0.0039/≤0.0039 | 0.125/0.25 |
IFM41633 | >64/8 | 0.125/0.0313 | ≤0.0039/≤0.0039 | 0.125/1 |
IFM46215 | >64/4 | 0.25/0.0156 | ≤0.0039/0.0078 | 0.5/1 |
IFM46930 | >64/4 | 0.25/0.0625 | ≤0.0039/≤0.0039 | 0.25/1 |
P. marneffei | ||||
IFM41707 | 16/NT | 0.25/NT | 0.0156/NT | 2/NT |
IFM41708 | 16/0.0313 | 0.25/0.25 | 0.0313/0.0625 | 2/4 |
IFM47279 | 16/2 | 0.5/0.25 | 0.0313/0.0156 | 2/2 |
IFM47280 | 8/2 | 0.25/0.125 | 0.0156/0.0078 | 1/2 |
IFM47281 | 4/2 | 0.25/0.25 | 0.0156/0.0156 | 1/4 |
S. schenckii | ||||
IFM46011 | >64/NT | 0.5/NT | 1/NT | 16/NT |
IFM46605 | 64/NT | 1/NT | 2/NT | >64/NT |
IFM46927 | 16/1 | 1/1 | 2/0.5 | >64/>64 |
IFM47068 | >64/0.5 | 1/1 | 2/1 | >64/>64 |
IFM46989 | NT/1 | NT/2 | NT/1 | NT/>64 |
IFM47069 | NT/1 | NT/2 | NT/1 | NT/>64 |
IFM46990 | NT/1 | NT/1 | NT/1 | NT/>64 |
C. immitis | ||||
IFM4935 | NT/0.0156 | NT/0.25 | NT/0.0625 | NT/4 |
IFM4945 | NT/0.0156 | NT/0.25 | NT/0.125 | NT/4 |
IFM45816 | NT/0.0156 | NT/0.0625 | NT/0.0625 | NT/4 |
IFM45868 | NT/0.0156 | NT/0.25 | NT/0.125 | NT/4 |
MICs were determined as minimum drug concentrations resulting in prominent growth inhibition compared with the growth control.
NT, not tested.