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Hypothetical model illustrating the regulation of CRE-dependent transcription by MBD2a according to the presence or absence of DNA methylation. In methylated CRE, MBD2a binds to methylated DNA involving CRE and represses transcription through association with the corepressor complex including HDAC1. In contrast, when CRE is not methylated, MBD2a promotes CRE-dependent gene expression as a cofactor via the interaction with RHA.
