TABLE 1.

Interactions between main Ca²⁺-to-NF-κB signaling pathways^a

Pathways	% Inhibition of NF-κB activity with inhibition of:								Pb	Commentc
	CaM	PKC	Akt	CNA	CaM + PKC	CaM + Akt	PKC + Akt	CNA + PKC
CaM + Akt	69		37			82			<0.05	+
CaM + PKC	56	23			68				<0.05	+
PKC + Akt		26	33				37		NS	=
PKC + CNA		42		61				80	<0.05	+

^aMain interactions between signaling pathways for NF-κB. All experiments where conducted as in Fig. 2. Calmodulin (CaM) was inhibited using W7; PKC and Akt pathways were blocked using BIM and wortmannin, respectively; and calcineurin (CNA) was inhibited by cyclosporine.

^bA P of <0.05 indicates significant differences determined by Student's test for double inhibition compared to each single inhibition. NS, not significantly different.

^cSymbols: =, the value resulting from inhibition of both pathways is equal to the lowest value resulting from inhibition of a single pathway; +, the percentage of inhibition obtained by inhibiting both pathways is lower than that resulting from inhibition of a single pathway.