Deletion of Murine Duffy Gene (Dfy) Reveals that the Duffy Receptor Is Functionally Redundant

Volume 20, no. 9, p. 3097-3101, 2002. Recently, we discovered that the spectrophotometric assay determinations for neutrophil-specific myeloperoxidase were wrong. We reported that in lipopolysaccharide inflammation in Dfy^−/− mice there was less enzymatic activity and, therefore, less neutrophil recruitment in the intestine and lungs than in wild-type animals. Now we find out that there is more neutrophil migration in mutants versus wild-type animals. These results are consistent with those published by T. C. Dawson et al. (Blood 96:1681-1684, 2000) and support the idea that mouse Duffy glycoprotein as a chemokine binding protein quenches chemokine activities and down regulates neutrophil trafficking.