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. 2003 Apr 1;111(7):1039–1045. doi: 10.1172/JCI17443

Figure 3.

Figure 3

Effect of mutant WNK4 on NCC-mediated 22Na uptake, expressed as nmol/h per oocyte. This figure compares rates of Na uptake (± SEM) of oocytes injected with cRNA encoding NCC and NCC + wild-type WNK4, E559K WNK4, D561A WNK4, and Q562E WNK4. Both wild-type and mutant WNK4 inhibited NCC activity (*P < 0.05 compared with NCC); Q562E reduced uptake significantly less than did wild-type WNK4 (#P < 0.05 compared with NCC+ WNK4). There were six experiments (15–30 oocytes per experiment).

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