Figure 5.

Protection conferred by reconstitution of WT mice with PPT-A gene–deleted (PPT-A^–/–) bone marrow and by capsaicin-selective denervation against inflammation (neutrophil counts in bronchoalveolar fluid; P = 0.0005) and increased alveolar-capillary permeability (Evans blue lavage fluid/serum ratio; P = 0.0014) 24 hours after a 4-hour period of high-volume ventilation. These results demonstrate, in a manner similar to that shown for immune complex–mediated inflammation (see Figure 3), that PPT-A gene expression by hemopoietic cells is critical for the progression of stretch-mediated inflammation. Values are shown as mean ± SE (n = 5 for WT-to-WT reconstitution and 4 for all other groups).