Table 2.
Effect of treatment on body temperature (in °C) and outcome. Effects on area under the curve measurements were adjusted for body temperature at start of treatment.
| Acetaminophen N = 25 | Ibuprofen N = 24 | Placebo N = 25 | |
| Temperature at 24 hrs (mean, SD) | 37.2 (0.5) | 37.2 (0.4) | 37.2 (0.5) |
| Difference with placebo (95% CI) | 0 (-.3 to 0.3) | 0 (-.3 to 0.3) | - |
| Change in temperature at 24 hrs, (mean, SD) | -0.1 (0.6) | 0.1 (0.6) | 0.2 (0.5) |
| Difference with placebo (95% CI) | 0.3 (0 to 0.6) | 0.1 (-.3 to 0.4) | - |
| Change in temperature after 5 days in(SD) | 0.3 (1.2) | 0.6 (1.6) | 0.1 (0.6) |
| Difference with placebo (95% CI) | -.2 (-1.0 to 0.7) | -.5 (-1.2 to 0.2) | - |
| Area under the curve (first 24 hours) in hrs × °C (SD) | 888 (12) | 883 (16) | 893 (14) |
| Difference with placebo (95% CI) | 7 (0 to 12) | 7 (2 to 12)) | - |
| Area under the curve (5 days) in hrs × °C (SD) | 4443 (63) | 4367 (128) | 4438 (64) |
| Difference with placebo (95% CI) | 9 (-52 to 34) | 23 (-15 to 62) | - |
| N of patients with Modified Rankin score >2, (%) | 13 (52%) | 9 (38%) | 12 (48%) |
| N of patients with Barthel index <20 (%) | 14 (56%) | 10 (42%) | 14 (56%) |