IL-1β release induced by DNFB in a fetal skin
dendritic cell line. Cells were stimulated with
2,4-dinitrofluorobenzene (DNFB, 1 μg/mL) or with
2,4-dichloronitrobenzene (DCNB, 1 μg/mL), for 30
minutes. Alternatively, cells were stimulated with GM-CSF
(10 ng/mL) alone, or in association with DNFB, for the same
time period. As a positive control, the cells were stimulated with
LPS (40 μg/mL), for 12 hours. IL-1β was quantified
with an ELISA kit. Data express the IL-1β release above the
basal secretion. Each value represents the mean ± SEM from
the indicated number of experiments, performed in duplicate.
Statistical significance was calculated by the one-way ANOVA test
with a Bonferroni post-test (∗∗∗ P < .001 as
compared to the control; ⩲⩲⩲ P < .001 as compared
to stimulation with DNFB).