. 2005 Aug 31;2005(4):185–193. doi: 10.1155/MI.2005.185

Table 1.

Effects of melatonin and 5-ASA on the macroscopical and histological damage indices and MPO activity in rats (x¯ ± s n = 10). ^a denotes that P < .01 versus the model group.


Group	Doses (mg.kg⁻¹)	Macroscopic index	Histological index	MPO activity (U.g⁻¹)
Normal	–	0.75 ± 0.71^a	1.1 ± 0.83^a	25 ± 19^a
Model	–	6.25 ± 1.39	6.24 ± 1.04	207 ± 26
5-ASA	100	1.60 ± 0.53^a	1.35 ± 0.47^a	126 ± 15^a
Melatonin	2.5	5.70 ± 1.21	5.85 ± 0.76	190 ± 20
Melatonin	5.0	3.00 ± 0.76^a	3.88 ± 0.99^a	155 ± 19^a
Melatonin	10.0	1.63 ± 0.74^a	1.38 ± 0.52^a	129 ± 31^a