Table 3.
Association between the VDR haplotypes and hand osteoarthritis (OA)
| Joint genotypea | Overall OA | Symmetrical OA | Osteophyte | |||
| Yes/no | Odds ratio (95% CI)b | Yes/no | Odds ratio (95% CI)b | Yes/no | Odds ratio (95% CI)b | |
| Aatt | 20/44 | 1.0 | 11/53 | 1.0 | 7/57 | 1.0 |
| AATt | 26/64 | 0.75 (0.35–1.61) | 14/75 | 0.73 (0.29–1.83) | 8/82 | 0.82 (0.2–2.56) |
| AATT | 5/15 | 0.68 (0.20–2.38) | 4/16 | 1.03 (0.26–4.08) | 3/17 | 1.62 (0.33–7.92) |
| AaTt | 43/111 | 0.75 (0.38–1.50) | 28/125 | 0.99 (0.43–2.25) | 5/149 | 0.26 (0.08–0.91) |
| AaTT | 34/80 | 0.89 (0.43–1.84) | 28/86 | 1.55 (0.67–3.54) | 9/105 | 0.70 (0.23–2.13) |
| AaTT | 32/69 | 1.00 (0.48–2.07) | 25/76 | 1.63 (0.70–3.82) | 7/94 | 0.61 (0.19–2.00) |
| At haplotype carriage | 89/219 | 0.87 (0.58–1.30) | 53/253 | 0.59 (0.38–0.93) | 20/288 | 0.76 (0.38–1.52) |
| AT haplotype carriage | 65/159 | 0.93 (0.62–1.41) | 46/177 | 0.96 (0.61–1.52) | 20/204 | 1.60 (0.78–3.27) |
| aT haplotype carriage | 109/260 | 1.03 (0.67–1.59) | 81/287 | 1.55 (0.94–2.56) | 21/348 | 0.51 (0.25–1.03) |
| No aT haplotypec | 51/123 | 1.0 | 29/144 | 1.0 | 18/156 | 1.0 |
| One aT haplotyped | 77/191 | 0.98 (0.62–1.54) | 56/213 | 1.43 (0.84–2.42) | 14/254 | 0.46 (0.21–1.00) |
| Two aT haplotypese | 32/69 | 1.20 (0.67–2.15) | 25/76 | 1.93 (1.01–3.70) | 7/94 | 0.65 (0.24–1.75) |
aA, absence of a restriction site; a, presence of a restriction site; T, absence of a restriction site; t, presence of a restriction site. bOdds ratio and 95% confidence interval (CI) adjusted for age (years), height (cm), occupation (1 = dentists, 2 = teachers [reference group]), hormone therapy (1 = ever used, 2 = never used [reference group]), current body mass index (1 = high, 2 = moderate, 3 = low [reference group]), daily calcium intake (1 = high [reference group], 2 = moderate, 3 = low), coffee consumption (number of cups per day), alcohol consumption (number of portion per week), and smoking history (1 = never smoked [reference group], 2 = ever smoked). cNo aT haplotype = AATT + AATt + AAtt.dOne copy of the aT haplotype = AaTT + AaTt. eTwo copies of the aT haplotype = aaTT.