. 2006 Jan 16;8(1):204. doi: 10.1186/ar1893

Table 1.

Patterns of anti-Epstein–Barr virus (EBV) serologies observed in different disease states

Disease state	VCA	EBNA-1	EBNA-2	EA	References
Early, acute primary EBV infection	IgA, IgM	Undetectable	↑↑	EA-D	[45,66]
Primary infection (weeks to months)	IgG	↑	↓	EA-R	[45,67]
Latent EBV infection in healthy host	Stable IgG	Stable	↓	Stable EA-R	[67]
Reactivation/EBV replication	↑↑ IgG	↑↑	↑	↑	[67-69,117]
Nasopharyngeal carcinoma^a	↑↑ IgG, IgA			↑ IgG, IgA	[70,118-120]
Burkitt's lymphoma^a	↑↑ IgG	↑	↑↑	↑	[70,121]
Multiple sclerosis^a	↑	↑	↑↑	↑	[111,112]
Systemic lupus erythematosus^a	↑	↑			[113,114]
Rheumatoid arthritis	↑	↑	↑	↑	[82-86,122]

EA, EBV early antigen; EA-D, EBV early antigen – diffuse; EA-R, EBV early antigen – restricted; EBNA, EBV nuclear antigen; VCA, EBV viral capsid antigen. ^aAbnormalities observed before disease onset.