Table 3.

Multivariable analyses of differences between offspring and controls in changes in cartilage measures

Outcome factor	Univariable analysis	β and 95% confidence interval
		Cartilagea	Cartilagea and BMI	Knee pain	Bone sizeb	Other outcomec	All factors
Differences in annual change in cartilage volume
Medial tibial (%)	-1.06 (-2.01,-0.10)	-0.77 (-1.61,+0.08)	-0.62 (-1.46,+0.23)	-0.89 (-1.88,+0.10)	-0.64 (-1.60,+0.31)	-0.71 (-1.57,+0.15)	-0.27 (-1.14,+0.60)
Lateral tibial (%)	-0.79 (-1.60,-0.00)	-0.55 (-1.32,+0.21)	-0.44 (-1.22,+0.33)	-0.55 (-1.43,+0.33)	-0.52 (-1.33,+0.29)	-0.75 (-1.59,+0.07)	-0.32 (-1.21,+0.56)
Patellar (%)	-0.98 (-1.83,-0.12)	-0.96 (-1.78,-0.15)	-0.74 (-1.56,+0.09)	-0.85 (-1.76,+0.06)	-1.01 (-1.87,-0.17)	-0.75 (-1.56,+0.06)	-0.55 (-1.37,+0.26)
Total (%)	-0.86 (-1.54,-0.17)	-0.71 (-1.33,-0.10)	-0.54 (-1.17,+0.09)	-0.69 (-1.40,+0.02)	-0.63 (-1.34,+0.07)	-0.60 (-1.23,+0.04)	-0.28 (-0.94,+0.38)
Differences in annual change in cartilage defects
Medial (number)	0.16 (0.00,0.32)	0.22 (0.07,0.38)	0.19 (0.05,0.34)	0.13 (-0.04,+0.31)	0.11 (-0.06,+0.27)	0.09 (-0.05,+0.23)	0.11 (-0.04,+0.26)
Patella (number)	0.09 (-0.05,+0.24)	0.14 (0.00,0.29)	0.12 (-0.03,+0.26)	0.09 (-0.06,+0.25)	0.08 (-0.06,+0.23)	0.05 (-0.09,+0.20)	0.07 (-0.07,+0.22)
Total (number)	0.26 (-0.06,+0.59)	0.41 (0.06,0.76)	0.32 (-0.01,+0.66)	0.23 (-0.12,+0.59)	0.16 (-0.17,+0.48)	0.11 (-0.19,+0.40)	0.19 (-0.13,+0.50)

Bold denotes statistical significance. ^aAdjusted for differences at baseline in cartilage volume (analyses of differences in change in cartilage volume) or in cartilage defects (analyses of differences in change in cartilage defects); ^badjusted for differences at baseline in bone size at this site; ^cadjusted for differences at baseline in annual change in cartilage defects (analyses of differences in change in cartilage volume) or in annual change in cartilage volume (analyses of differences in change in cartilage defects).