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. 2006 Feb 13;8(2):R42. doi: 10.1186/ar1897

Figure 2.

Figure 2

Combined IL-10/tumor necrosis factor (TNF)α genotype influences TNFα serum levels in SLE patients without antimalarial treatment. After determination of the allele present at positions -1,082 and -308 of the IL-10 and TNFα gene promoters, respectively, patients were classified as genetically high (GG) or low (AA/AG) IL-10 producers and high (AA/AG) or low (GG) TNFα producers. Box plots represent TNFα serum levels in SLE patients not receiving antimalarial therapy classified according to the four possible IL-10/TNFα combined genotypes. Differences were evaluated by the Mann-Whitney U test.