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. 2006 Feb 24;8(2):R46. doi: 10.1186/ar1902

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Copyright © 2006 Kapral et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Adjusted cumulative retention rates of MTX therapies. Based on a Cox proportional hazards regression model, cumulative retention rates for original therapies (grey lines; oMTX) and re-employed therapies (black lines; rMTX) are shown adjusted for the use in 1999 or later and methotrexate dose (lines for oMTX and rMTX are plotted at the cohort mean of these covariates). Re-employed courses showed a significant lower Hazard Ratio of treatment discontinuation compared to the original courses (P = 0.04). All courses that were ongoing, lost to follow up, or terminated because of incompliance were censored in this analysis.