Table 2.

Treatment terminations for ineffectiveness in original and re-employed methotrexate therapies

		Re-employed course		Total
		No inefficacy	Inefficacy
Original course	No inefficacy	19 (9.7 ± 3.1/11.4 ± 4.9)	9 (10.0 ± 4.0/15.8 ± 6.5)	28 (9.8 ± 3.3/12.9 ± 5.8)
	Inefficacy	23 (11.8 ± 4.5/16.8 ± 5.6)	28 (14.5 ± 5.3/18.8 ± 5.2)	51 (13.3 ± 5.1/17.9 ± 5.4)
Total		42 (10.9 ± 4.1/14.4 ± 5.9)	37 (13.5 ± 5.3/18.1 ± 5.6)	79 (12.1 ± 4.8/16.1 ± 6.0)

The numbers in parentheses are the doses in the original methotrexate/re-employed methotrexate courses (mean ± standard deviation) in mg/week). The percentage of patients who were concordant for the presence or absence of inefficacy was 60.3% (P = 0.022, by McNemar test).