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Detection of CTR mRNA in sections of human peri-implant tissues. The techniques used were in situ hybridization with a 35S-labeled antisense RNA probe ((a, c) bright field and (b, d) dark field). Expression of CTR mRNA is evident only in multinuclear cells in contact with the bone surface (panels a and b). Cells associated with polyethylene (PE) particles do not express detectable CTR mRNA (panels c and d).
