TABLE 2.
Phenotypes of ray axon guidance mutants
| Genes (alleles) | Ray axon defect | Defects in other axons | Major pleiotropic defect | Additional phenotypes | Mating efficiencya |
|---|---|---|---|---|---|
| rax-1(bx126, bx132) | Lateral to ventral | No | Ray axon specific | No | ME3 |
| rax-4(bx139) | Lateral to ventral | No | No | ME1 | |
| rax-3(bx133, bx138) | Multiple defectsb | ND | Cell migration | Slightly loopy movement, anterior cell migration | ME2 |
| rax-2 (bx131) | Multiple defects | Ectopic neurons with pkd-2∷gfp | Slightly long, anterior cell migration | ND | |
| rax-5(bx137) | Multiple defects | No | Ray differentiation | Ray fusion | ME2 |
| rax-6(bx140) | Multiple defects | No | Ray fusion | ME3 | |
| bx141 | Ectopic neurites | ND | Control of outgrowth | ND | ND |
| sax-2(bx130) | Ectopic neurites | Sensory neurons | Gonad dysmorphology | ME1 | |
| unc-27(bx124,bx127) | Wandering | Many | Muscle attachment | Unc | ME1 |
| unc-6(bx123) | Lateral to ventral | Many | Global guidance molecules | Unc | ND |
| unc-40(bx134) | Lateral to ventral | Many | Unc | ||
| unc-51(bx135) | Lateral to ventral | Many | Unc |
Mutations are grouped according to their common axonal and pleiotropic defects.
a
Mating efficiency is estimated by the percentage of cross progeny from mutant males relative to the wild-type males. ME4 = 40–100% of wild-type male mating efficiency; ME2 = 20–40%; ME3 = 10–20%, ME = 1–10%.
b
Multiple defects include outgrowth, guidance, and fasciculation.