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. 2003 Mar 15;31(6):1605–1613. doi: 10.1093/nar/gkg259

Figure 6.

Figure 6

Schematic representation of the various platinum bis-chelates formed upon reaction of AG3(T2AG3)3 I with cis- and trans-[Pt(NH3)2(H2O)2]2+ 1 and 2, respectively (a), (b), (c) and (d). The cross mimics the four bonds of the square planar complex. Both I and II gave the same cross-links. Only structure A is used because structure B (Fig. 1) cannot account for any of the chelates compatible with the sites actually platinated (see text). Only bis-chelates are represented in order to limit the number of figures. They include the cross-links of the single chelates. It is noteworthy that the latter are the major products formed with 2 (bands 2.4, Fig. 3). (a) The A1–G10 and A13–G22 chelates of cis-Pt(NH3)2 were found as single chelates in band 1.2 and as a bis-chelate in band 1.1 (Fig. 2). The same cross-link was also formed by 2 on II (band 2.1, Fig. 3). (b–d) The three bis-chelates formed upon reaction of 2 with I have the same A7–A19 cross-link at the bottom of the quadruplex structure and different chelates at the top: respectively A1–A13, A1–G10 and A13–G22 (band 2.2, Fig. 3).