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(A) Growth arrest can be induced by template mutant telomerase. tlc1-Δ cells were transformed with the indicated plasmids well before the onset of replicative senescence. (B) Two template sequences of death- inducing template RNAs. The tetranucleotide 3′-ACGC-5′ is present in both lethal templates, but also in complementing RNA templates from Library477–473 (21, identical with 29) and Library480–471 (59). It is therefore not solely responsible for the lethal effect.
